The relationship between uric acid levels and Huntington's disease progression
Identifieur interne : 001950 ( Main/Exploration ); précédent : 001949; suivant : 001951The relationship between uric acid levels and Huntington's disease progression
Auteurs : Peggy Auinger [États-Unis] ; Karl Kieburtz [États-Unis] ; Michael P. Mcdermott [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-01-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Biological Markers (blood), Disease Progression, Female, Humans, Huntington Disease (blood), Huntington Disease (diagnosis), Huntington Disease (physiopathology), Huntington disease, Huntington's disease, Male, Middle Aged, Movement, Nervous system diseases, Prognosis, Randomized Controlled Trials as Topic, Severity of Illness Index, Time Factors, Uric Acid (blood), Uric acid, progression, uric acid.
- MESH :
- chemical , blood : Biological Markers, Uric Acid.
- blood : Huntington Disease.
- diagnosis : Huntington Disease.
- physiopathology : Huntington Disease.
- Adult, Aged, Disease Progression, Female, Humans, Male, Middle Aged, Movement, Prognosis, Randomized Controlled Trials as Topic, Severity of Illness Index, Time Factors.
Abstract
Uric acid (UA) may be associated with the progression of Parkinson's disease and related neurodegenerative conditions; however, its association with Huntington's disease (HD) progression has not been explored. A secondary analysis of 347 subjects from the CARE‐HD clinical trial was performed to examine the relationship between baseline UA levels and the level of functional decline in HD. Outcomes included change in scores at 30 months for the Unified Huntington's Disease Rating Scale components. There was less worsening of total functional capacity over time with increasing baseline UA levels (adjusted mean worsening in scores: 3.17, 2.99, 2.95, 2.28, 2.21, from lowest to highest UA quintile, P = 0.03). These data suggest a possible association between higher UA levels and slower HD progression, particularly as measured by total functional capacity. If confirmed, UA could be an important predictor and potentially modifiable factor affecting the rate of HD progression. © 2009 Movement Disorder Society
Url:
- https://api.istex.fr/document/600962A0251CB74FF3391D05035604C8104C4E44/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831113
DOI: 10.1002/mds.22907
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-01-30">2010-01-30</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="224">224</biblScope><biblScope unit="page" to="228">228</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">600962A0251CB74FF3391D05035604C8104C4E44</idno><idno type="DOI">10.1002/mds.22907</idno><idno type="ArticleID">MDS22907</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biological Markers (blood)</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Huntington Disease (blood)</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (physiopathology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Movement</term><term>Nervous system diseases</term><term>Prognosis</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Uric Acid (blood)</term><term>Uric acid</term><term>progression</term><term>uric acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biological Markers</term><term>Uric Acid</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement</term><term>Prognosis</term><term>Randomized Controlled Trials as Topic</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Acide urique</term><term>Chorée de Huntington</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Uric acid (UA) may be associated with the progression of Parkinson's disease and related neurodegenerative conditions; however, its association with Huntington's disease (HD) progression has not been explored. A secondary analysis of 347 subjects from the CARE‐HD clinical trial was performed to examine the relationship between baseline UA levels and the level of functional decline in HD. Outcomes included change in scores at 30 months for the Unified Huntington's Disease Rating Scale components. There was less worsening of total functional capacity over time with increasing baseline UA levels (adjusted mean worsening in scores: 3.17, 2.99, 2.95, 2.28, 2.21, from lowest to highest UA quintile, P = 0.03). These data suggest a possible association between higher UA levels and slower HD progression, particularly as measured by total functional capacity. If confirmed, UA could be an important predictor and potentially modifiable factor affecting the rate of HD progression. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Auinger, Peggy" sort="Auinger, Peggy" uniqKey="Auinger P" first="Peggy" last="Auinger">Peggy Auinger</name></region><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael P." last="Mcdermott">Michael P. Mcdermott</name><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael P." last="Mcdermott">Michael P. Mcdermott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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